Liquid Chromatography - Mass Spectrometry (LC - MS)

Liquid chromatography–mass spectrometry is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry.

Mass spectrometry is an Instrumental technique in which sample is converted to rapidly moving positive or negative ions by electron bombardment and charged particles are separated according to their masses

Mass spectrum is a plot of relative abundance against the ratio of mass/charge (m/z)

LC-MS is used for the separation of Components and Determination of Molecular Mass of the components in a sample. The samples can be analysed using different interfaces like ESI and APCI probes.